Figure 1.

Clinical subtypes and sample clustering using RNA-seq data. (A) Clinical subtypes of PE patients: early-onset severe PE (EOSPE), late-onset severe PE (LOSPE), late-onset mild PE (LOMPE). The numbers under each subtype are the numbers of placentae (outside the brackets) and the numbers of patients (inside the brackets). (B) Principal component analysis (PCA). The top two principal components in this dataset represent up to 30% of all variations. Samples of EOSPE clustered on the right side (within the dashed circle), while samples of LOSPE and LOMPE are clustered together with normal samples on the left side. (C) Heatmap of sample-sample distance using the Ward's method. The EOSPE samples are clustered as the branch on the left, roughly corresponding to the samples in the right area of the PCA plot. The LOSPE and LOMPE samples are clustered together with normal samples on the right side. Four LOSPE samples were clustered with EOSPE.