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. 2021 Mar 5;11(10):5028–5044. doi: 10.7150/thno.56141

Figure 4.

Figure 4

Functional classification of differentially expressed transporter genes. (A) The overlapping genes between the transporter genes and DEGs. Of the identified transporter genes, 205 were differentially expressed in EOSPE and 23 genes in LOSPE. (B) Fraction of transport genes in DEGs. The transporter genes were collected from Gene Ontology. Gray bar represents the expected fraction (7.87%) of transporter genes in all GO annotated genes (19,738), the fraction of transporter genes in the DEGs of EOSPE samples (8.92%), the DEGs of LOSPE (7.14%). The transporter genes were significantly enriched in the DEGs of EOSPE, but not in LOSPE. One-sided Fisher's exact test was used to calculating the P-values. Error bars represent the standard error of the fraction, estimated using bootstrapping method with 100 resamplings. (C) Gene-GO term bipartite network for enriched GO BP terms and DEGs in EOSPE and LOSPE. Blue dashed circles show 5 biological process clusters involved in different transportation processes of substrates and materials. Group I: ion channels; group II: macro-autophagy; group III: transmembrane transportation of nonlipid nutrients; group IV: transmembrane transportation of lipids; group V in transportation of hormone. In the LOPSE, the group A: ion channels; group B: transportation of chloride, carboxylic acid, cAMP and anion. Blue dashed circles show 2 biological process clusters. Red nodes represent up-regulated transporter genes and blue nodes down-regulated transporter genes, and yellow diamond nodes represent GO BP terms. The edges indicate the GO BP terms the genes belong to.