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. 2021 Mar 4;11(10):4825–4838. doi: 10.7150/thno.55330

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Metabolomic change of islets isolated from SIRT2-KO rats. (A) Overview of metabolic profiles. Metabolomics data were obtained from islet extracts (n=6). (B) Main down-regulated metabolic pathways obtained from differential metabolites of SIRT2-KO islets compared with SIRT2-WT islets. (C) Schematic representation of intermediates in glycolysis and TCA cycle. The relative levels of indicated metabolites are shown on both sides. Data are expressed as means ± SEM. ^*P< 0.05, ^**P< 0.01 vs WT rats.