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. 2021 Mar 5;11(10):4957–4974. doi: 10.7150/thno.55075

Figure 4.

Figure 4

Influences of increased tumor PD-L1 on cellular and molecular responses of T cells. (A) The expression profile of cytokines in Tnull and TCR-TMART-1. (B) The expression distribution of IL13 and IL5 in Tnull and TCR-TMART-1 responding to PD-L1high. (C) The expression profile of chemokines in Tnull and TCR-TMART-1. (D) The expression distribution of CCL4 and CCR5 in T cell clusters of Tnull and TCR-TMART-1 responding to differential proportions of PD-L1+ tumor. (E) The expression profile of transcription factors in Tnull and TCR-TMART-1. (F) The expression distribution of NKFB1, GATA3, HIF1A, STAT4, TBX21, IRF8, and STAT1 in TCR-TMART-1 responding to differential proportions of PD-L1+ tumor. (G) The violin showing the expression levels of STAT3, IRF4, CEBPB, and AHR in TCR-TMART-1 responding to differential proportions of PD-L1+ tumor.