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. 2021 Mar 5;11(10):4957–4974. doi: 10.7150/thno.55075

Figure 6.

Figure 6

Increased expression of tumor PD-L1 affected death of tumor cells and T cells without direct correlation. (A) GSVA analysis of cell death pathways in tumor cells (top) and violin plot showing the expression level of PD-L1 in tumor cells (bottom). (B) GSVA analysis of cell death pathways in tumor cells either expressing PD-L1 or not. (C) GSVA analysis of cell death pathways in different tumor clusters. (D) The expression levels of PDL1 among cancer clusters. (E) GSVA analysis of cell death pathways in different subsets of T cells. (F) The expression of CD274 in Tnull and TCR-TMART-1 responding to differential proportions of PD-L1+ tumor. (G) The percentage (left) and intensity (right) of PD-L1 expression on tumor cells after incubation with MEL-526 cells for 24 h. (H) The expression distribution of apoptotic genes in T cell clusters of TCR-TMART-1 responding to differential proportions of PD-L1+ tumor.