Skip to main content
. 2021 Mar 4;11(10):4567–4584. doi: 10.7150/thno.56995

Figure 4.

Figure 4

Physiological and histological observations for mice received different administration of AN2728, PNPs, DPNPs, or Dsg3 antibody. Mice were intradermally injected with 100 µl of 1 mg/ml free AN2728 or different nanoparticles or 2.5 µg Dsg3 antibody in PBS on Day 1, 3, and 5. Tissue samples of heart, liver, spleen, lung, kidney, skin, and blood were collected on Day 6: (A) The gross images of mouse back skin were represented on Day 6 by digital camera. (B) The close-up images by hand-held digital microscopy. (C) Skin sections represented by H&E staining. (D) TEWL. (E) skin surface pH value. (F) erythema quantification. H&E staining of (G) heart, (H) liver, (I) spleen, (J) lung, and (K) kidney. Scale bars, 100 µm. Blood biochemical parameters of (L) GOT, (M) GPT, (N) CRE, and (O) BUN. Scale bars, 100 µm. Data are expressed as mean ± SEM (n=6).