Table 1. Composition of prepared in situ gel formulations.
| Ingredients | Batch code | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M1 | M2 | M3 | M4 | M5 | M6 | M7 | M8 | M9 | M10 | M11 | M12 | M13 | M14 | |
| Gellan gum (% w/v) | 0.5 | 0.7 | - | - | 0.5 | 0.7 | 0.5 | 0.7 | - | - | - | - | - | - |
| Sodium alginate (% w/v) | - | - | 0.3 | 0.5 | 0.3 | 0.3 | 0.3 | 0.3 | - | - | - | - | - | - |
| Poloxamer 188 (% w/v) | - | - | - | - | - | - | - | - | 18 | 25 | - | - | - | - |
| Poloxamer 407 (% w/v) | - | - | - | - | - | - | - | - | - | - | 18 | 25 | - | - |
| Carbopol 940P (% w/v) | - | - | - | - | - | - | - | - | - | - | - | - | 0.2 | 0.4 |
| HPMC (% w/v) | - | - | - | - | - | - | 0.4 | 0.4 | 0.5 | - | 0.5 | - | 0.5 | - |
| Methyl cellulose (% w/v) | - | - | - | - | 0.5 | 0.5 | - | - | - | 0.5 | - | 0.5 | - | 0.5 |
| Phosphate buffer pH 7.4 (ml) | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | - | - | - | - | - | - |
| Acetate buffer pH 6.5 (ml) | - | - | - | - | - | - | - | - | 100 | 100 | 100 | 100 | - | - |
| Boric acid buffer pH 4.7 (ml) | - | - | - | - | - | - | - | - | - | - | - | - | 100 | 100 |
Amount of moxifloxacin incorporated in all formulations is 0.5% w/v. HPMC–Methocel F4M Premium USP.