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. Author manuscript; available in PMC: 2021 Mar 19.
Published in final edited form as: N Engl J Med. 2018 Nov 1;379(18):1732–1744. doi: 10.1056/NEJMoa1801550

Table 3.

Multivariable Log-Binomial Regression Model to Identify Variables Associated with Health Care–Associated Infections, Combined 2011 and 2015 Survey Populations.*

Variable Total No. of Patients No. of Patients with Infection Adjusted Risk Ratio (95% Cl) P Value
Survey year 2015 12,299 394 0.84 (0.74–0.95) 0.005
Ventilator on the survey date 1,113 176 1.63 (1.38–1.92) <0.001
Central catheter on the survey date§ 4,202 472 1.84 (1.59–2.13) <0.001
Urinary catheter on the survey date 4,958 312 1.24 (1.07–1.44) 0.004
Large hospital 4,909 280 1.20 (1.05–1.37) 0.007
Time from admission to survey
 ≤1 day 7,022 27 Reference
 2–4 days 9,013 81 2.15 (1.41–3.38) <0.001
 5–6 days 2,154 76 7.14 (4.67–11.26) <0.001
 7–9 days 1,834 127 12.97 (8.71–20.05) <0.001
 ≥10days 3,557 535 25.45 (17.54–38.58) <0.001
Age**
 <40yr 7,217 172 Reference
 40–50 yr 2,185 88 1.50 (1.17–1.89) <0.001
 51–57 yr 2,277 114 1.67 (1.33–2.08) <0.001
 58–65 yr 3,048 140 1.45 (1.17–1.78) <0.001
 66–72 yr 2,703 104 1.39 (1.10–1.75) 0.005
 73–80 yr 2,815 113 1.56 (1.24–1.95) <0.001
 ≥81yr 3,335 115 1.65 (1.31–2.07) <0.001
*

The total number of patients who were included in either survey was 23,581. One patient from the 2011 survey for whom age was unknown was excluded from the model. Other variables that were tested but found not to be significant predictors of the risk of health care–associated infection were survey month (May or June vs. July through September) and location of the patient in a critical care unit (yes vs. no).

The comparator group for the risk ratio was the group of patients in the 2011 survey.

The comparator group for the risk ratio was the group of patients without a ventilator or for whom the presence of a ventilator was unknown. The presence of a ventilator was unknown for 36 patients without a health care–associated infection and for 1 with a health care–associated infection.

§

The comparator group for the risk ratio was the group of patients without a central catheter or for whom the presence of a central catheter was unknown. The presence of a central catheter was unknown for 62 patients without a health care–associated infection and for 2 with a health care–associated infection.

The comparator group for the risk ratio was the group of patients without a urinary catheter or for whom the presence of a urinary catheter was unknown. The presence of a urinary catheter was unknown for 65 patients without a health care–associated infection and for 5 with a health care–associated infection.

The comparator group for the risk ratio was the group of patients in small or medium hospitals.

**

The model excluded 1 patient without a health care–associated infection for whom age was unknown.