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. 2021 Mar 19;66:103288. doi: 10.1016/j.ebiom.2021.103288

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Clinical outcomes. (a) Bar chart of daily clinical status according to the WHO 7-point ordinal scale. (b,c) Cumulative estimates of (b) time to sustained clinical improvement (c) time to weaning from oxygen (d) Evolution of SARS-CoV-2 viral load from nasopharyngeal swabs assessed by RT-qPCR. Samples were available from 31 patients. Box plot shows median and interquartile range. Whiskers are drawn at (Q3 + 1.5 x IQR, Q 1- 1.5 x IQR). (e) Exposure-Response relation between itraconazole trough concentrations and cumulative clinical score day 1-15. Q1, Q3 denotes 1^st and 3^rd quartile, WHO denotes World Health Organization, IQR interquartile range.