Figure 5.

Correlation of kynurenines and PGE₂ concentrations with the number of proliferating T cells. PBMCs stimulated with PHA were cocultured with TNF + IFNγ- (TI-) treated ASCs from HD (a–d) and AS patients (e–h). The proliferation of CD4⁺ (a, c, e, g) and CD8⁺ (b, d, f, h) cells was evaluated, and the measurement of kynurenines and PGE₂ concentrations was performed as described in Materials and Methods. Spearman's rank (Rs) (a, b, e, f) and Pearson's (R) (c, d, g, h) correlation coefficients and P values are shown. Other explanations as in Figure 1.