Figure 6.

Selective inhibitors of kynurenines (1-MT) and PGE₂ (indomethacin) synthesis counteract inhibitory effect of ASCs on proliferation of CD4⁺ T cells. Cell preparation and culture conditions as in Figure 1. The concentrations and time of cell treatment with 1-MT and indomethacin (Indo) are described in Materials and Methods. Data are shown as the Tukey's boxes; the number of performed experiments (n) is shown. ^∗P = 0.05‐0.01, ^∗∗P = 0.01‐0.001, and ^∗∗∗P = 0.001‐0.0001 for comparison of cell cocultures vs. control separate cultures. ^#P = 0.05‐0.01, ^##P = 0.01‐0.001, and ^###P = 0.001‐0.0001 for comparison of inhibitor treated vs. untreated cocultures. Other explanations as in Figure 1.