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The impact of ALA on DNA methylation status estimated in the kidneys of control rats after 4 and 8 weeks of treatment. (a) Global level of DNA methylation measured by ELISA-based assay. Levels of mRNA of Dnmt1 (b), Dnmt3a (c), and Tet1 (d) expressions in the kidneys as determined by RT-qPCR. mRNA levels are relative to Actb. ∗p < 0.05 compared to the control group of animals.
