Table 6.
Antihyperglycemic Activity of Isolates in STZ-Induced Diabetic Mice
| Treatment Group | Fasting Blood Glucose Level mg/dl | ||||
|---|---|---|---|---|---|
| Fbg0 | Fbg7 | Fbg14 | Fbg21 | %Redn | |
| (normal) 2% DMSO | 122.17 ± 8.09 | 129.50 ± 6.48 | 123.33 ± 4.43 | 119.00 ± 2.89 | 2.46 |
| (diabetic) 2% DMSO | 314.00 ± 19.73 | 329.17 ± 16.2 | 336.33 ± 16.88 | 352.83 ± 16.19 | − 12.37 |
| 200 mg/kg Ia | 312.00 ± 17.28 | 299.17 ± 16.51 | 290.33 ± 15.55 | 290.17 ± 17.28 | 6.99 |
| 400 mg/kg Ia | 299.83 ± 12.99 | 280.33 ± 14.31 | 276.17 ± 17.22 | 261.17 ± 16.33** | 12.89 |
| 200 mg/kg Ib | 355.83 ± 26.88 | 305.83 ± 24.41 | 291.00 ± 22.74 | 259.67 ± 19.88** | 27.02 |
| 400 mg/kg Ib | 318.50 ± 38.97 | 283.17 ± 25.29 | 242.50 ± 12.95** | 203.5 ± 13.19*** | 36.1 |
| 200 mg/kg Ic | 290.50 ± 16.69 | 275.33 ± 16.94 | 267.67 ± 16.00 | 283.17 ± 19.05 | 2.5 |
| 400 mg/kg Ic | 339.67 ± 16.31 | 316.17 ± 22.97 | 291.33 ± 24.10 | 285.17 ± 25.21 | 16.04 |
| 2 mg/kg GA | 325.83 ± 34.87 | 234.67 ± 13.79* | 174.30 ± 5.78*** | 135.83 ± 8.01*** | 58.3 |
Notes: Data are expressed as Mean ± Standard Error of Mean (SEM); n=6; Where *significant values at p<0.05 compared with group II; ** Significant values at p<0.01 compared with group II; *** Significant values at p<0.001 compared with group II.
Abbreviations: DMSO, dimethyl sulfoxide; GA, glibenclamide; % redn, percent of reduction; Ia, isolate a; Ib, isolate b; Ic, isolate c.