Table 1 |.
Patient characteristics and Pentraxin-2 levels by patient group
| Characteristic | Normal (n = 15) | Mild NAFL (n = 15) | Moderate fibrosis (n = 15) | Advanced fibrosis (n = 15) | P* | P† |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age, mean (s.d.), years | 59.2 (5.7) | 58.9 (5.2) | 56.5 (5.6) | 61.1 (4.4) | 0.1468 | 0.5944 |
| Female, n (%) | 12 (80.0%) | 8 (53.3%) | 11 (73.3%) | 10 (66.7%) | 0.5195 | 0.7096 |
| Race/ethnicity, n (%) | ||||||
| White | 13 (86.7%) | 8 (53.3%) | 5 (33.3%) | 9 (60.0%) | 0.0648 | |
| Black | 0 | 1 (6.7%) | 0 | 0 | ||
| Hispanic | 2 (13.3%) | 3 (20.0%) | 6 (40.0%) | 6 (40.0%) | ||
| Asian | 0 | 2 (13.3%) | 3 (20.0%) | 0 | ||
| Refused | 0 | 1 (6.7%) | 1 (6.7%) | 0 | ||
| Anthropometric, mean (s.d.) | ||||||
| Body mass index, kg/m2 | 25.6 (5.9) | 28.9 (3.1) | 32.1 (5.8) | 33.4 (4.1) | 0.0003 | <0.0001 |
| Clinical, n (%) | ||||||
| Diabetes mellitus | 0 | 3 (20.0%) | 8 (53.3%) | 7 (46.7%) | 0.0020 | 0.0011 |
| Hypertension | 4 (26.7%) | 5 (33.3%) | 8 (53.3%) | 13 (86.7%) | 0.0045 | 0.0005 |
| Hypertriglyceridemia | 1 (6.7%) | 5 (33.3%) | 5 (33.3%) | 3 (20.0%) | 0.2490 | 0.4128 |
| Laboratories, mean (s.d) | ||||||
| Albumin (g/dL) | 4.5 (0.3) | 4.6 (0.2) | 4.6 (0.2) | 4.4 (0.3) | 0.1581 | 0.1552 |
| AST (U/L) | 22.3 (6.4) | 36.9 (21.7) | 47.5 (34.7) | 58.2 (25.8) | 0.0014 | <0.0001 |
| ALT (U/L) | 18.9 (7.0) | 51.0 (35.4) | 73.7 (61.6) | 58.0 (32.2) | 0.0030 | 0.0030 |
| Bilirubin, total (mg/dL) | 0.4 (0.2) | 0.6 (0.3) | 0.5 (0.3) | 0.7 (0.8) | 0.3972 | 0.1346 |
| Platelet count (1000/mm3) | 257.3 (47.9) | 252.6 (53.9) | 246.9 (49.4) | 182.1 (56.4) | 0.0007 | 0.0004 |
| International normalised ratio | 1.0 (0.1) | 1.0 (0.1) | 1.0 (0.1) | 1.1 (0.1) | 0.0019 | 0.0009 |
| Fasting serum glucose (mg/dL) | 92.7 (10.0) | 101.3 (15.4) | 112.4 (24.1) | 116.1 (36.3) | 0.0362 | 0.0044 |
| Haemoglobin A1c (%) | 5.8 (0.3) | 5.9 (0.3) | 6.2 (0.7) | 6.4 (0.6) | 0.0041 | 0.0004 |
| Triglycerides (mg/dL) | 102.4 (69.0) | 151.1 (72.2) | 156.0 (68.9) | 179.5 (184.2) | 0.2858 | 0.0687 |
| HDL cholesterol (mg/dL) | 66.8 (16.5) | 56.4 (14.8) | 50.9 (13.5) | 45.4 (12.8) | 0.0013 | 0.0001 |
| LDL cholesterol (mg/dL) | 108.5 (34.6) | 120.1 (36.3) | 101.5 (39.8) | 93.3 (31.8) | 0.2353 | 0.1330 |
| C-reactive protein (mg/L) | 1839.9 (3030.8) | 2294.7 (3493.3) | 4002.6 (4870.4) | 3874.9 (2717.2) | 0.2593 | 0.0670 |
| Pentraxin-2 (μg/mL), mean (95% CI) | ||||||
| Unadjusted | 80.2 (63.7–96.7) | 23.7 (7.2–40.2) | 22.0 (5.5–38.6) | 12.2 (4.3–28.7) | <0.0001 | <0.0001 |
| Age, gender adjusted | 85.2 (68.0–102.5) | 24.2 (7.9–40.6) | 25.3 (8.1–42.5) | 15.4 (1.6–32.5) | <0.0001 | <0.0001 |
| Age, gender, albumin adjusted | 85.2 (67.8–102.6) | 24.1 (7.6–40.6) | 25.3 (8.0–42.7) | 16.0 (1.5–33.5) | <0.0001 | <0.0001 |
| Age, gender, CRP adjusted | 86.5 (68.9–104.2) | 24.9 (8.4–41.4) | 24.5 (7.1–41.9) | 14.9 (−2.3–32.0) | <0.0001 | <0.0001 |
*
Continuous variables were analysed with ANOVA, categorical variables were analysed with Fisher’s exact test. The P values in bold are statistically significant.
†
Test of linear trend.