Table 2 |.
Biopsy and MRE characteristics by patient group
| Normal (n = 15) | Mild NAFL (n = 15) | Moderate fibrosis (n = 15) | Advanced fibrosis (n = 15) | P* | P† | |
|---|---|---|---|---|---|---|
| NAFLD Activity Score, (NAS) | ||||||
| Mean (s.d.) | – | 3.6 (1.0) | 5.2 (0.9) | 5.5 (1.2) | <0.0001 | <0.0001 |
| 2 | – | 2 (13.3%) | 0 | 0 | 0.0059 | |
| 3 | – | 5 (33.3%) | 0 | 0 | ||
| 4 | – | 5 (33.3%) | 3 (20.0%) | 4 (26.7%) | ||
| 5 | – | 3 (20.0%) | 7 (46.7%) | 4 (26.7%) | ||
| 6 | – | 0 | 4 (26.7%) | 3 (20.0%) | ||
| 7 | – | 0 | 1 (6.7%) | 4 (26.7%) | ||
| Lobular inflammation (score), (no. foci per 200 × field), n (%) | ||||||
| None (0) | – | 0 | 0 | 0 | 0.0004 | |
| <2 foci (1) | – | 10 (66.7%) | 1 (6.7%) | 2 (14.3%) | ||
| 2–4 foci (2) | – | 5 (33.3%) | 14 (93.3%) | 10 (71.4%) | ||
| >4 foci (3) | – | 0 | 0 | 2 (14.3%) | ||
| Steatosis | ||||||
| Grade, n (%) | ||||||
| <5% (0) | – | 0 | 1 (6.7%) | 0 | 0.2244 | |
| 5–33% (1) | – | 9 (60.0%) | 3 (20.0%) | 6 (40.0%) | ||
| 33–66% (2) | – | 5 (33.3%) | 8 (53.3%) | 5 (33.3%) | ||
| >66% (3) | – | 1 (6.7%) | 3 (20.0%) | 4 (26.7%) | ||
| Ballooning (score), n (%) | ||||||
| None (0) | – | 6 (40.0%) | 1 (6.7%) | 0 | 0.0010 | |
| Few (1) | – | 7 (46.7%) | 9 (60.0%) | 3 (21.4%) | ||
| Many (2) | – | 2 (13.3%) | 5 (33.3%) | 11 (78.6%) | ||
| MRE, mean (s.d.) | 2.2 (0.3) | 2.3 (0.3) | 2.8 (0.3) | 5.6 (1.3) | <0.0001 | <0.0001 |
*
Continuous variables were analysed with ANOVA, categorical variables were analysed with Fisher’s exact test. The P values in bold are statistically significant.
†
Test of linear trend.