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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Brain Behav Immun. 2020 Dec 21;93:66–79. doi: 10.1016/j.bbi.2020.12.014

Figure 4: Behavioral outcomes of adult male and female offspring of dams exposed to aerosolized PBS or OVA in early or late gestation.

Figure 4:

Pregnant female mice were exposed to either aerosolized PBS or OVA during early (GD2-GD9) or late (GD10-GD17) gestation and offspring were tested in adulthood with the elevated plus maze and marble burying tasks (A-D). Reported is (A) total time adult offspring spent in the open arm of the elevated plus maze; (B) total time in the Closed arms of the elevated plus maze; (C) percent of time offspring spent in the open arm of the elevated plus maze as a percentage of the total time spent in both open and Closed arms; (D) number of marbles buried in the marble burying task. * p < 0.05 compared to Early-PBS as determined by linear mixed effects modeling with treatment and timing as fixed effects and litters as random effects. Open dots represent individual mice; bars represent marginal means +/− SE. Early-PBS (7 litters) males n = 17, females n = 21; Early-OVA (6 litters) males n = 16, females n = 17; Late-PBS (6 litters) males n = 18, females n = 14. Late-OVA (5 litters) males n = 17, females n = 16. EPM - elevated plus maze.