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. Author manuscript; available in PMC: 2022 Mar 17.
Published in final edited form as: Neuron. 2021 Jan 27;109(6):938–946.e5. doi: 10.1016/j.neuron.2021.01.006

Figure 1.

Figure 1.

Kv3.3 KO or Kv3.3G592R KI inhibits slow endocytosis at calyces

(A) Sampled ICa and mean Cm trace (mean + s.e.m) induced by depol20ms (arrow) from WT (10 calyces, 10 mice), Kv.3.3−/− (10 calyces, 10 mice) and Kv3.3G592R (10 calyces, 10 mice) calyces from P7–10 mice at 22–24°C. s.e.m. is plotted every 1 s.

(B) Ratedecay, ΔCm and QICa (mean + s.e.m.) induced by depol20ms at WT (10 calyces, 10 mice, black), Kv.3.3−/− (10 calyces, 10 mice, red) and Kv3.3G592R (10 calyces, 10 mice, blue) calyces from P7–10 mice at 22–24°C. **: p < 0.01 (t test).

(C) The Cm change (mean + s.e.m.) and Ratedecay (mean + s.e.m.) induced by depol20ms (arrow) at WT (7 calyces, 7 mice) and Kv3.3G592R (7 calyces, 7 mice) calyces from P7–10 mice at 34–37°C. **: p < 0.01 (t test).

(D) Similar to C, except from P13–14 mice at 22–24°C. WT: 8 calyces, 8 mice; Kv3.3G592R: 7 calyces, 7 mice.