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. Author manuscript; available in PMC: 2022 Mar 19.
Published in final edited form as: Circ Res. 2021 Feb 3;128(6):690–705. doi: 10.1161/CIRCRESAHA.120.317458

Figure 4. LpL deficiency (+/− hCETP) does not affect macrophage phenotype.

Figure 4.

Macrophage phenotype was assessed by isolating mRNA from atherosclerotic CD68+ macrophages using Laser Capture Microdissection and mRNA expression measured for (A) Metabolism-related genes (B) Inflammatory genes (C) Anti-inflammatory genes. Additionally, immunofluorescence staining of atherosclerotic arches was performed for (D-E) Arginase-1 (%cells per total cells) and (F-G) iNOS (%cells per total cells), scale bars = 500 μm. N= (A-C) Lplfl/fl +hCETP 5, Lpl−/− + hCETP 5; (E, G) Lplfl/fl 6, Lpl−/− 5, Lplfl/fl +hCETP 6, Lpl−/− + hCETP 5. Data represented as mean ± SEM, * P < 0.05, (A-C) unpaired t-test, (E, G) 1-way ANOVA with Tukey’s multiple comparison test.