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(A) From the original T1-weighted volume, the outer contour of the gray matter is traced, and then surrounded by a smooth enclosing surface. (B) When done as a 3D surface, this results in the pial (blue) and enclosing (green) surfaces. (C) The gyrification index (GI) is the ratio of the cortical surface area divided by the surface area of the enclosing surface.
