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. 2020 Oct 1;31(4):2568–2579. doi: 10.1007/s00330-020-07130-y

Table 3.

Histopathological tumor characteristics stratified by mammographic findings

Mass Calcifications Asymmetry Distortion
n = 777 n = 242 n = 106 n = 97
Histopathological type
  DCIS 23 3% (2, 4)* 145 60% (53, 66) 9 9% (4, 16)* 3 3% (1, 9)*
  Invasive carcinoma of NST 646 83% (80, 86)* 85 35% (29, 42) 78 74% (64, 82)* 69 71% (61, 80)*
  ILC 54 7% (5, 9)** 5 2% (1, 5) 14 13% (7, 21)* 20 21% (13, 30)*
  Other invasive carcinomas 54 7% (5, 9) 7 3% (1, 6) 5 5% (2, 11) 5 5% (2, 12)
Invasive cancer 754 97 97 94
Histological grade
  Grade 1 211 28% (25, 32) 13 14% (8, 23) 26 28% (1, 38) 38 41% (31, 52)*
  Grade 2 378 51% (47, 54) 42 45% (34, 55) 51 54% (44, 65) 47 51% (40, 62)
  Grade 3 158 21% (18, 24)* 39 41% (31, 52) 17 18% (11, 27)* 7 8% (3, 15)*
  Data not available 7 3 3 2
Lymph node status
  Negative 583 80% (77, 83) 73 85% (76, 92) 74 80% (70, 87) 67 74% (64, 83)
  Data not available 28 28 11 4 4
Hormonal status
  ER positive 661 90% (88, 92) 75 85% (76, 92) 89 95% (88, 98) 92 100% (96, 100)*
   Data not available 21 9 3 2
  PR positive 532 73% (70, 76)* 47 54% (43, 65) 69 73% (63, 82) 80 87% (78, 93)*
   Data not available 24 10 3 2
Mammographic diameter (mm)
  Mean ± SD 15 mm ± 8*, ** 36 mm ± 26 17 mm ± 16* 22 mm ± 15*
  Median (IQR) 13 mm (9, 18) 30 mm (17, 50) 13 mm (9, 20) 20 mm (14, 25)
  Data not available 45 7 7 4
Tumor diameter (mm)
  Mean ± SD 15 mm ± 8 12 mm ± 11 16 mm ± 12 20 mm ± 15*
  Median (IQR) 12 mm (9, 18) 9 mm (5, 17) 14 mm (8, 17) 15 mm (12, 22)
  Data not available 11 9 0 2

Unless otherwise specified, data are the number of patients and 95% confidence interval in parentheses

DCIS ductal carcinoma in situ, NST no special type, ILC invasive lobular carcinoma, ER estrogen receptor, PR progesterone receptor, SD standard deviation, IQR interquartile range

*p < 0.001, compared with calcifications; **p < 0.001, compared with distortion