Table 4.
Histopathological type, tumor diameter, and histological grade for mammographic findings stratified by review categories
| True | Missed | Minimal signs | ||||
|---|---|---|---|---|---|---|
| Mass | n = 336 | n = 185 | n = 256 | |||
| Histopathological type | ||||||
| DCIS | 9 | 3% (1, 5) | 7 | 4% (2, 8) | 7 | 3% (1, 6) |
| Invasive carcinoma of NST | 291 | 87% (83, 90) | 149 | 81% (74, 86) | 206 | 81% (75, 85) |
| ILC | 17 | 5% (3, 8) | 11 | 6% (3, 10) | 26 | 10% (7, 15) |
| Other invasive carcinomas | 19 | 6% (3, 9) | 18 | 10% (6, 15) | 17 | 7% (4, 10) |
| Tumor diameter of invasive cancer | ||||||
| Mean ± SD | 14 mm ± 8 | 15 mm ± 9 | 14 mm ± 8 | |||
| Median (IQR) | 12 mm (9, 18) | 13 mm (10, 18) | 12 mm (9, 19) | |||
| Not available | 5 | 3 | 3 | |||
| Histological grade of invasive cancer | ||||||
| Grade 1 | 72 | 22% (18, 27) | 61 | 35% (28, 42) | 78 | 31% (26, 38) |
| Grade 2 | 150 | 47% (41, 52) | 96 | 54% (47, 62) | 132 | 53% (47, 59) |
| Grade 3 | 99 | 31% (26, 36) | 20 | 11% (7, 17)* | 39 | 16% (11, 21)* |
| Not available | 6 | 1 | 0 | |||
| Asymmetry | n = 58 | n = 15 | n = 33 | |||
| Histopathological type | ||||||
| DCIS | 5 | 9% (3, 19) | 4 | 12% (3, 28) | ||
| Invasive carcinoma of NST | 46 | 79% (67, 89) | 10 | 67% (38, 88) | 22 | 67% (48, 82) |
| ILC | 4 | 7% (2, 17) | 15 | 33% (12, 62) | 5 | 15% (5, 32) |
| Other invasive carcinomas | 3 | 5% (1, 14) | 2 | 6% (1, 20) | ||
| Tumor diameter (mm) of invasive cancer | ||||||
| Mean ± SD | 14 mm ± 11 | 20 mm ± 9 | 16 mm ± 14 | |||
| Median (IQR) | 13 mm (8, 16) | 19 mm (15, 24) | 14 mm (8, 16) | |||
| Not available | ||||||
| Histological grade of invasive cancer | ||||||
| Grade 1 | 10 | 20% (10, 34) | 2 | 13% (2, 41) | 14 | 48% (29, 68) |
| Grade 2 | 26 | 52% (37, 66) | 10 | 67% (38, 88) | 15 | 52% (33, 71) |
| Grade 3 | 14 | 28% (16, 43) | 3 | 20% (4, 48) | ||
| Not available | 3 | |||||
| Calcifications | n = 128 | n = 46 | n = 68 | |||
| Histopathological type | ||||||
| DCIS | 83 | 65% (56, 73) | 23 | 50% (35, 65) | 39 | 57% (45, 69) |
| Invasive carcinoma of NST | 39 | 31% (23, 39) | 21 | 46% (31, 61) | 25 | 37% (25, 49) |
| ILC | 3 | 2% (1, 7) | 1 | 2% (0, 12) | 1 | 2% (0, 8) |
| Other invasive carcinomas | 3 | 2% (1, 7) | 1 | 2% (0, 12) | 3 | 4% (1, 12) |
| Tumor diameter of invasive cancer | ||||||
| Mean ± SD | 13 mm ± 12 | 11 mm ± 10 | 12 mm ± 9 | |||
| Median (IQR) | 10 mm (6, 15) | 6 mm (4, 11) | 10 mm (5, 19) | |||
| Not available | 5 | 2 | 2 | |||
| Histological grade of invasive cancer | ||||||
| Grade 1 | 6 | 14% (5, 27) | 3 | 14% (3, 36) | 4 | 14% (4, 32) |
| Grade 2 | 18 | 41% (26, 57) | 10 | 48% (26, 70) | 14 | 48% (29, 68) |
| Grade 3 | 20 | 45% (30, 61) | 8 | 38% (18, 62) | 11 | 38% (21, 58) |
| Not available | 1 | 2 | ||||
| Distortion | n = 43 | n = 20 | n = 34 | |||
| Histopathological type | ||||||
| DCIS | 1 | 2% (0, 12) | 2 | 10% (1, 32) | ||
| Invasive carcinoma of NST | 29 | 67% (52, 81) | 14 | 70% (46, 88) | 26 | 77% (59, 89) |
| ILC | 11 | 26% (14, 41) | 4 | 20% (6, 44) | 5 | 15% (5, 31) |
| Other invasive carcinomas | 2 | 5% (1, 16) | 3 | 9% (2, 24) | ||
| Tumor diameter (mm) of invasive cancer | ||||||
| Mean ± SD | 19 mm ± 13 | 21 mm ±14 | 20 mm ± 17 | |||
| Median (IQR) | 16 mm (10, 22) | 17 mm (12, 22) | 15 mm (12, 22) | |||
| Not available | 1 | 1 | ||||
| Histological grade of invasive cancer | ||||||
| Grade 1 | 15 | 37% (2, 53) | 7 | 41% (18, 67) | 16 | 47% (30, 65) |
| Grade 2 | 22 | 54% (37, 69) | 8 | 47% (23, 72) | 17 | 50% (32, 68) |
| Grade 3 | 4 | 10% (3, 23) | 2 | 12% (2, 36) | 1 | 3% (0, 15) |
| Not available | 1 | 1 | ||||
Unless otherwise specified, data are the number of patients and 95% confidence intervals in parentheses
DCIS ductal carcinoma in situ, NST no special type, ILC invasive lobular carcinoma, ER estrogen receptor, PR progesterone receptor, SD standard deviation, IQR interquartile range
*p < 0.001, compared with true.