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. 2021 Mar 19;11:6470. doi: 10.1038/s41598-021-85871-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Manhattan-Style plots of regional heritability across the genome for hearing difficulty (top), and tinnitus (bottom). Estimated local SNP heritability for 1702 loci. Blue denotes an estimate of local_h2g = 0.0006, P < 1.157E−05 on Chr 5 for hearing difficulty in the region between base positions 71240456–73759326. HESS total SNP heritability estimates were 0.1, SE = 0.005 for hearing difficulty and 0.0853, SE = 0.013 for tinnitus.