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. 2021 Mar 19;5:23. doi: 10.1038/s41698-021-00163-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Changes in TILs between baseline and day 15 according to hormone receptor [HR] status, subtype (HER2-enriched [HER2-E]) and response (pathological complete response [pCR] vs residual disease [RD]). Lines are coloured according to TIL dynamics: increase (red), stable (blue) or decrease (green). b Changes in TIL levels between day 15 and surgery according to response: pathological complete response [pCR] vs residual disease [RD]. Lines are coloured according to TIL dynamics: increase (red), stable (blue), or decrease (green). c Changes in TIL levels between baseline, day 15 and surgery in the overall study cohort and according to response (pathological complete response [pCR] vs residual disease [RD]), hormone receptor [HR] status and PAM50 subtype. Lines are coloured according to TIL dynamics: increase between baseline and day 15 followed by an increase between day 15 and surgery (red); increase between baseline and day 15 followed by stable or decrease between day 15 and surgery (orange); stable or decrease between baseline and day 15 followed by an increase between day 15 and surgery (blue); stable or decrease between baseline and day 15 followed by stable or decrease between day 15 and surgery (green). d Venn diagram representing overlaps in genes upregulated in relation to increase in TIL levels across the three timepoints.