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. 2021 Mar 19;12:1722. doi: 10.1038/s41467-021-21954-2

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

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Fig. 5 — Heatmap of neutralization titers (IC₈₀ μg ml⁻¹) of 24 monoclonal antibodies against a panel of 55 R3 influenza A viruses. Virus subtypes are color-coded and indicated at the bottom of the heatmap. Open and closed circles indicate specificity of monoclonal antibodies and are shown on the right of the heatmap (open, HA head-; closed, HA stem-directed). Convergent classes of bnAbs with specific gene signatures are indicated on the left of the heatmap as triangles (gray, V_H1-69; black, V_H6-1 + D_H3-3; open, V_H1-18 QxxV). Heatmap and unsupervised clustering was made with the ClustVis server (https://biit.cs.ut.ee/clustvis/). Note: H1N1 and H3N2 viruses are R3∆PB1 and all other viral subtypes are R3∆HA viruses. Neutralization assays were performed at least twice and representative data are plotted.