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. 2021 Mar 19;12:1758. doi: 10.1038/s41467-021-22021-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Immunostaining for DMC1 (red), DDX4 (green), and DAPI (blue) in Stra8^+/+ and Stra8⁻^/− SSC cultures (left panels) and testicular cross sections (right panels). Scale bars, 10 µm. The numbers below the immunofluorescent images indicate the percentage of cells seen with DMC1 staining under different genotypes. b (Left) UHC and heatmap of gene expression in SSC cultures with indicated genotypes for 2 days. (Right) Top GO enrichments with representative genes in each cluster. c GSVA analysis for indicated genotypes. In the heatmap, rows are defined by the selected gene sets, and columns by consensus scores for each genotype. Group enriched gene sets are highlighted by different color. d, e Venn plots with top GO enrichments and representative genes for (d) NRRA-upregulated and (e) NRRA-downregulated genes in Stra8^+/+ and Stra8^−/− cultures. Data are representative of (a) three independent experiments (SSC cultures under NRRA treatment) or mice from each genotype.