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. 2021 Mar 19;12:1750. doi: 10.1038/s41467-021-21955-1

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021, corrected publication 2022

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Fig. 4 — a LMIV230-01 bound to gametes of St. Lucia parasite strain and b of an isolate obtained from a Malian adult and adapted to culture. c Murine anti-48/45 mAb confirms formation of gametes by Malian isolate and its signal colocalizes with LMIV230-01. “Merged” refers to combination of green and red channels. d Membrane attack complex forms on gametes of St. Lucia strain and (e) of a Malian isolate incubated with LMIV230-01 in the presence of intact but not heat-inactivated serum. All imaging experiments shown in this figure were performed in duplicate. Scale bars for all images in this panel: 5 µM. f Cartoon schematizing LMIV230-01 competition ELISA assay. g Distribution of serum antibody levels that compete with LMIV230-01 for binding to Pfs230D1 in 36 subjects who received Pfs230D1-EPA vaccine. Values displayed represent mean from three independent experiments. h Relationship of LMIV230-01-competing antibody levels to total Pfs230D1 antibody titers, or (i) to serum functional activity (TBA, transmission-blocking activity) measured by SMFA. Source data are provided as a Source Data file.