Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 19;12:1789. doi: 10.1038/s41467-021-22065-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a The enhanced slowing response to the food of worms at indicated ages. Sensing the food reduces worm movement (body bends). The worms at day 10 of adulthood are over the reproductive age and exhibit ageing features. n = 3 (day 1) or n = 4 (day 10) biological independent experiments. p = 0.0078 and 0.2493, respectively. b. The DiI staining is decreased in the sensory neurons of aged worms (n = 66 and 62 animals respectively. p = 0.0001.). Arrows denote the soma of sensory neurons. Scale bar: 10 μm. c. A depiction of IFT in sensory cilia, which are at the dendritic endings of sensory neurons. IFT-B complex and kinesin control the anterograde IFT, whereas IFT-A complex and dynein modulate the retrograde IFT. d–f IFT decreases with ageing. Representative IFT components were examined at indicated ages. The representative kymographs (d), velocities (e) and frequencies (f) are respectively shown. For d, similar results were obtained in all independent experiments. Exact sample size and p value are included in Source Data file. (+) and (−) denote microtubule polarity. Horizontal scale bars: 2 μm; vertical scale bars: 2 s. Data are presented as mean ± SEM in e and mean ± SD in the rest. Two-way ANOVA in e, and unpaired t-test (two-tailed) in the rest, **p < 0.01, ***p < 0.001, ns non-significant. Source data are provided as a Source Data file.