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. 2021 Mar 19;11:6472. doi: 10.1038/s41598-021-85960-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mitochondrial activity and mass of human IL-12/15/18-stimulated NK cells. (A) Representative experiment of Seahorse XF analyzer with the Mito Stress Test kit. Means ± standard deviation are depicted. (B) Bar charts representing spare respiratory capacity (SRC), measured as the difference between maximal and basal mitochondrial respirations. (C) Bar charts representing mitochondrial mass, measured as the median fluorescence intensity (MFI) of MitoTracker Green. Graphs show data of control NK cells and IL-12/15/18-stimulated NK cells (activated NK) (Day 0, left column), and after 7 days of culture with IL-15 (control NK or CIML NK) or IL-2 (CIML NK + IL-2) (Day 7, right column). Means ± SEM are depicted in bar graphs. Statistical analyses were performed using Wilcoxon matched-pairs signed rank test. Each dot represents an independent experiment from a different donor (n = 5–8). *P < 0.05.