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. 2021 Mar 19;12(4):297. doi: 10.1038/s41419-021-03566-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A The hazard ratios of the LASSO selected 18 genes. B Kaplan–Meier curve for the overall survival (OS) of AML patients classified by the median of Gene-18 risk score. C Receiver-operating characteristic (ROC) curve of the Gene-18 risk score. D Kaplan–Meier curve for the overall survival (OS) of AML patients classified by the Gene-18 risk score in the validated set. E The correlation of circSPI1-regulated 18-gene risk score and circSPI1 expression. F Correlation matrix of circSPI1 and circSPI1-regulated 18 genes. RNA quantification analysis was performed on the transcriptomic data of AML patients with enough sequencing depth that enabled the identification of both linear SPI1 and circSPI1. The Pearson method was used to assess the correlations among circSPI1 and circSPI1-regulated genes. G The correlation of HSPA8 and circSPI1 expression. H Expression levels of HSPA8 were analyzed in AML patients and normal subjects. I Kaplan–Meier curve for the overall survival (OS) of AML patients with high or low HSPA8 expression levels. J HSPA8 was essential for the survival of AML cells. Normalized read counts of sgRNA in AML cells transfected with the CRISPR-cas9/sgRNA library before and after population doublings are shown.