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Drug effective doses (ED) on reducing viral titers according to the level of viral inoculum.
| Virus inoculum | ED50 mg/day (95%CIa) |
ED90 mg/day (95%CIa) |
ED99 mg/day (95%CIa) |
|---|---|---|---|
| Preemptive therapy | |||
| 104 TCID50 | 34 (30–37) | 42 (38–46) | 53 (48–58) |
| 105 TCID50 | 26 (21–30) | 37 (31–44) | 56 (46–65) |
| 106 TCID50 | 15 (10–20) | 31 (21–41) | 70 (48–93) |
| Preventive therapy | |||
| 104 TCID50 | 27 (25–29) | 35 (32–38) | 47 (44–51) |
Dose–response curves are presented in Supplementary Fig. 3.
a95% confidence interval.
