Table 4.

Multivariate analysis of independent prognostic factors of HPSCC.

Variable	Hazard ratio (95% CI)	p value
Tumor size (≥3 vs. <3)	1.97 (1.27–3.57)	0.0352
Lymphatic metastasis (N1–3 vs. N0)	2.79 (1.65–4.68)	0.0265
Distant metastasis (Yes vs. No)	4.35 (2.04–6.87)	0.0125
TNM stage ((III/IV vs. I/II)	3.16 (2.07–6.15)	0.0086
circCUX1 (High vs. Low)	2.83 (1.74–5.02)	0.0167