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. 2021 Mar 19;11:6479. doi: 10.1038/s41598-021-86023-6

Table 1.

Clinical characteristics of patients.

Patient Communication Self injury/aggression Comorbidity Medication ID grade Mode of transportation
F59

Laughs, screams for hours,

bites hand

Self injury

CP, epilepsy

Diabetes type 1

Scoliosis

Insulin

Carbamazepine

Ramipril

S Wheelchair
F31 Smiles, facial expression of fear, reaches for objects None

Rett syndrome

Epilepsy

Osteoporosis

Scoliosis

Carbamazepine

Levetiracetam

Valproate

S Wheelchair
F18 Screams, bites Both

Autism

Epilepsy

Scoliosis

Carbamazepine

Clonazepam

Aripiprazole

Omeprazole

S Fully ambulant
M54 Speaks a few short phrases Aggressive behavior

Diabetes type 1

Polyneuropathy

Insulin

Gabapentin

S Fully ambulant
F58 Some signs with her hands. Murmuring Self injury

Epilepsy

Hip dysplasia

Phenobarbital S Wheelchair
M62 Facial expression, sounds None

Scoliosis

Hip fracture

S Ambulant + wheelchair
F 36 Smiles, moaning, screams, grimacing None

CP/quadriplegia

Tuberous sclerosis

Hiatal hernia

Valproate

Acetylcysteine

Methenamine

S Wheelchair
M48 Hand or head movements Self injury

CP

Spasticity

Epilepsy

Lacosamide

Levetiracetam

Topiramate

Phenobarbital

P Wheelchair
M 37 A few words, body language Self injury

Epilepsy

Hypertension

Spina bifida

Candesartan

Amlodipine

Lamotrigine

Levetiracetam

S Wheelchair
F56 Facial expression, laughter, shouting None

CP

Scoliosis

Baclofen

Pantoprazole

Mo Wheelchair
M27

Smiles, body movements

Some signs

Both

Epilepsy

Autism

Valproate

Levetiracetam

Clobazam

Rufinamide

P Fully ambulant
F22 Eye movement, vague facial expressions, howling None

Rett syndrome

Epilepsy

Scoliosis

Lamotrigin

Valproate

S Wheelchair
F14 Facial expressions, some body movements Both

CP, Epilepsy

Impaired vision

Insomnia

Zonizamid

Clobazam

Lamotrigin

Valproate

S Wheelchair
M18 Some facial expression, repetitive sounds, movement of head and arms None

Hurler syndrome

Epilepsy

Paraplegia

Valproate

Melatonin

S Wheelchair

Sex and age (first column), modes of expession, presence of aggressive or self-injurious behavior, comorbidities, medication, degree of intellectual disability, and mode of transportation in 14 non-communicating persons with ID. Abbreviations: CP: cerebral palsy, F: female, ID: intellectual disability, M: male, Mo: moderate ID (IQ 35–49), S: severe ID (IQ 20–34). P: profound ID (IQ < 20).