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. 2021 Mar 19;12:1717. doi: 10.1038/s41467-021-22033-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a IFNAR1 levels on CD15⁺ PMN (left) and CD14⁺ Mon (right) from whole blood of healthy donors (HD) or cancer patients (CP). Individual results in 6 healthy donors and 22 cancer patients are shown. Mean ± SD of IFNAR1 expression is presented. P values were calculated in Mann–Whitney test. b IFNAR1 measured on PMN versus PMN-MDSCs (n = 3) or Mon versus M-MDSCs (n = 4) from the same patients. Fold change from IFNAR1 level in PMN or Mon in each patient is shown. c IFNAR1 levels on mouse splenic PMN-MDSCs and M-MDSCs from indicated s.c. tumor models analyzed by flow cytometry. Each dot represents the geometric mean of IFNAR1 levels in individual mice (n = 4 for B16 model, n = 7 for LLC mode, n = 4 for CT26 model). d IFNAR1 levels on splenic PMN-MDSCs and M-MDSCs from spontaneous tumor models analyzed by flow cytometry. Fold change over spleen of tumor-free mice (n = 3 for RET model, n = 5 for KPC model PMN-MDSC and n = 4 for M-MDSC). Mean and SD is shown. e IFNAR1 levels on PMN-MDSCs and M-MDSCs from spleen and indicated ascites tumors analyzed by flow cytometry. Each dot represents an individual mouse (n = 4 for EL4 model, n = 3 for MethA model). IFNAR1 levels is presented as fold changes from spleen cells. f IFNAR1 levels on PMN-MDSCs and M-MDSCs from spleen and mechanically dissociated tumors analyzed by flow cytometry. Each dot represents the geometric mean of IFNAR1 levels in individual mice. (n = 5 for B16-F10 and CT26 models and n = 4 for LLC model). In all panels, data are expressed as mean ± SD and the p values were calculated using unpaired two-sided Student’s t test. ns—p > 0.05.