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. 2021 Mar 19;12:1744. doi: 10.1038/s41467-021-21999-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a FEM simulated scattering cross-section spectrum for AuNPs on a resonant PC surface. b Contour map of the PC enhancement factor on the AuNP scattering cross section as a function of AuNP diameter and excitation wavelength. c Schematic illustration of the PRISM system (upper) and interferometric scattering microscopy (iSCAT) with a gold disk placed in the Fourier plane to attenuate the reference beam (lower). d Representative differential interferometric images of AuNPs (d = 40 nm) obtained by PRISM (left) and iSCAT (right). e Comparison of signal contrast obtained respectively by PRISM (red) and iSCAT (blue). n > 400 for each size of AuNP.