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. 2021 Mar 19;12:1744. doi: 10.1038/s41467-021-21999-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a False-colored SEM image of an inactivated SARS-CoV-2 virion on the PC substrate. b Contrast histogram obtained from over 500 individual virus signals. c, e Representative interferometric image with additional identifiers (white arrows) for coronaviruses and ferritin molecules within the field-of-view. d Distribution of contrast signal from individual ferritin (440 kDa, contrast: 0.88 ± 0.09%) and fibrinogen (340 kDa, contrast: 0.77 ± 0.09%). n > 1000 for each protein molecule.