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. 2021 Mar 19;11:6453. doi: 10.1038/s41598-021-85733-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Clustering of gene expression for R-Arm (black lines) and ER-Arm (blue lines) RNASeq at different time points (0 min, 90 min). K-means clustering based on gene expression and fold-changed in individual time points identified 7 cluster with distinct expression profiles (A). Pathway analysis of individual clusters by GSEA, with genes ranked by fold-change/standard deviation ratio identified both distinct and common pathways, shown as upset-plot (B). Pathways exclusive to individual clusters with their respective normalized enrichment score (NES) are plotted with their p-value indicated by color (C). Only single pathway (Smad2/3 nuclear signaling) has been identified for cluster 2 and is not shown. Expression profiles of selected genes for individual clusters (D–H). Expression profiles of selected genes that either play role in protein synthesis or show interesting complementary expression patterns (I).