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. 2021 Mar 19;12:1741. doi: 10.1038/s41467-021-21755-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Ai Ribbon assembly of abstract v6 x-slats (blue) and y-slats (gold). Upper pathway shows transient association of free slats, where the critical nucleus (c.n.) requires a multitude of unfavorable slat additions. Lower pathway uses a seed (light green) to capture twelve nuc-y-slats (dark green) along with six x-slats. Aii, Subsequent slats (magenta) are recruited in alternating perpendicular fashion for ribbon growth. Aiii, Qualitative energy landscape for unseeded (orange) versus seeded (green) nucleation and growth of slats using irreversible growth conditions. B Each binding domain in the abstract model is a half turn of DNA. C Crisscross polymerization of ssDNA slats (blue x- and gold y-slats) as triggered by a DNA-origami seed (light green). Straight cylinders represent double helices. D Left are negative-stain TEM images of v6 (n = 6) and v8 (n = 8) ribbons, in (i) and (ii), respectively. Right models show width differences, where each boxed cell is a single half-turn domain. Light-red or dark-red cells correspond to either five or six base-pair domains. Scale bars are 50 nm.