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. 2021 Mar 19;12:1745. doi: 10.1038/s41467-021-22001-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Four-way Venn diagram showing the number of shared and non-shared persulfidated proteins identified in liver, kidney, muscle, and brain in cystathionine γ-lyase (CGL) wildtype (WT) mice. A total of 209 persulfidated proteins were shared amongst all four organs. n = 9 mice total; 4/AL group and 5/DR group. b KEGG biological function and pathway enrichment of the shared 209 proteins found in liver, kidney, muscle, and brain via g:Profiler analysis. c, d Four-way Venn diagrams showing shared and non-shared persulfidated proteins enriched under AL (c) and DR (d) feeding. e–g KEGG biological function and pathway enrichment of AL enriched (blue bars) or DR enriched (green bars) persulfidated proteins in liver (e), kidney (f), and brain (g). The numbers within the bars indicate individual persulfidated proteins identified for that specific pathway. Statistical significance for pathway enrichment plotted as the adjusted −log₁₀ (P value) and was auto-calculated via the g:Profiler g:SCS algorithm for KEGG database that utilizes multiple testing corrections. See also Supplementary Fig. 3.