Fig. 3. Infection by NMI ∆dot/icm does not cause fever in guinea pigs.

a Body temperatures were recorded daily from the day of infection (day 0) until the day of euthanasia (day 14). b Temperatures were plotted for each individual animal per time point throughout the duration of infection. Fever was defined as ≥39.5 °C and is indicated by the dotted line. Fever duration c and maximum body temperature at any given point post-infection d are presented for each animal. These two endpoints were evaluated based on differences in group means (horizontal bar) with associated confidence intervals. Error bars represent standard deviation. For each reported comparison, p-values were computed at the α = 0.05 level for two-sided two-sample t tests, allowing for unequal variances between groups. No adjustment was made for multiple comparisons due to the sample sizes (n = 4) and the descriptive nature of the study. **p ≤ 0.01.