Table 1.
Experimental descriptions.
| Experiment 1—Virulence | ||
| Infection > 14 Days > Euthanasia | ||
| Infection strain | Sample size | |
| Saline | 4 | |
| aNMI | 4 | |
| bNMII | 4 | |
| cNMI Δdot/icm | 4 | |
| Experiment 2 – Vaccine Efficacy | ||
| Vaccination > 28 Days > Infection > 14 Days > Euthanasia | ||
| Vaccine strain | Infection strain | Sample size |
| Saline | Saline | 3 |
| Saline | NMI | 4 |
| NMI | NMI | 4 |
| Q-VAX® | NMI | 4 |
| NMII | NMI | 4 |
| NMI Δdot/icm | NMI | 4 |
| Experiment 3—Post-vaccination hypersensitivity | ||
| Infection > 42 Days > Skin Test > 21 Days > Euthanasia | ||
| Infection strain | Skin test strain | Sample size |
| Saline | Saline | 4 |
| Saline | NMI | 4 |
| NMI | Saline | 4 |
| NMI | NMI | 4 |
| NMI | dNMC | 4 |
| NMI | NMII | 4 |
| NMI | NMI ?dot/icm | 4 |
aNMI: Nine Mile I RSA493
bNMII: Nine Mile II RSA439
cNMI ∆dot/icm: Nine Mile I RSA493 with dot/icm deletion
dNMC: Nine Mile Crazy RSA514