Skip to main content
. 2021 Mar 16;62(3):22. doi: 10.1167/iovs.62.3.22

Figure 2.

Figure 2.

Mitophagy protein signaling mechanisms. (A) PINK1/parkin-mediated mitophagy. Following the stabilization of PINK1 to the OMM, possibly by BNIP3, parkin is recruited to the OMM, resulting in the phosphorylation of parkin by PINK1. This event then triggers parkin to polyubiquitinate an OMM protein (VDAC), which then recruits a phagophore through proteins p62 and LC3. Interactions between the polyubiquitinated OMM protein and LC3/p62 initiate the mitophagy process. (B) Non-parkin-mediated mitophagy is initiated through proteins on the OMM (FUNDC1, NIX, or BNIP3) that bind directly to LC3 on the phagophore membrane, initiating the mitophagy process. (C) Non-parkin, syntaxin 17 (STX17)-mediated mitophagy occurs when the expression of FIS1 is downregulated, allowing for the accumulation of STX17 proteins on the OMM. The accumulation of STX17 proteins on the OMM recruits ATG14, which interacts with LC3 on the phagophore membrane.