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. 2021 Mar 20;7(1):veab020. doi: 10.1093/ve/veab020

Figure 4.

Figure 4.

Mutations and sites under positive selection in endemic HCoV and IAV glycoprotein genes. (A–C) Average rate of non-synonymous mutations (dN) and indel mutations at each position along the glycoprotein genes of HCoV-229E, HCoV-OC43, and IAV H3N2 are depicted in green (dN) and brown (indel). Sites under positive selection are depicted as red bars below gene sketches. The HCoV-229E RBD position is based on GenBank accession no. MH048989 according to Li et al. (2019). The HCoV-OC43 RBD position is based on GenBank accession no. AY903460 according to Hulswit et al. (2019). The IAV H3N2 RBD position is based on GenBank accession no. CY173187 according to DuBois et al. (2011).