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Schematics of IFITM3 antiviral activity and functional polymorphisms.
(A) IFITM3 at the endosomal membrane blocks entry of viruses, such as influenza A virus. (B) IFITM3 at the plasma membrane limits subsequent infectivity of budding viruses, such as HIV-1. (C) The indicated single-nucleotide polymorphisms (SNPs) in human IFITM3 impact its antiviral function and influence control of virus replication. IFITM3, interferon-induced transmembrane protein 3.
