Table 3.

Predicted ADME/T properties

Compounds	Polar surface area	LogP	BBB permeability	CNS permeability	Total clearance	Hepatotoxicity
1e	139.63	3.0607	− 0.221	− 2.403	0.743	No
3a	174.309	7.3887	0.777	− 1.746	0.589	No
4b	127.66	6.6914	0.853	− 1.399	0.986	No
4n	206.31	− 0.559	− 1.742	− 4.092	1.576	No
5b	185.387	10.1412	1.029	− 1.066	2.152	No
5c	179.022	9.7511	1.004	− 1.054	2.13	No