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. 2021 Mar 20;184(9):2384–2393.e12. doi: 10.1016/j.cell.2021.03.036

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Cell entry mediated by the S proteins of SARS-CoV-2 variants B.1.351 and P.1 is partially or fully resistant to inhibition by monoclonal antibodies with EUA

Pseudotypes bearing the indicated S proteins were incubated (30 min, 37°C) with different concentrations of control antibody (hIgG), four different monoclonal antibodies (Casirivimab, Imdevimab, REGN10989, Bamlanivimab), or a combination of Casirivimab and Imdevimab, as present in the REGN-CoV2 antibody cocktail, before being inoculated onto target Vero cells. Transduction efficiency was quantified by measuring virus-encoded luciferase activity in cell lysates at 16–20 h post-transduction. For normalization, inhibition of S protein-driven entry in samples without antibody was set as 0%. Presented are the data from a single experiment performed with technical triplicates. Data were confirmed in a separate experiment. Error bars indicate standard deviation (SD). See also Figure S2.