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. 2021 Mar 20;10:100140. doi: 10.1016/j.mtadv.2021.100140

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 2 — (A) Electrostatic potential maps (in kT/e) SARS-CoV-2 and ACE2 shown in a cartoon view [31]. (B) The structure of PVBzA, PPAA, PVPA, and PAEP and antiviral activities of 14 polyanions [34]. (C) Synthesis and characterization of PEI-man_n [42]. (a) Synthetic scheme and chemical structure of mannose-functionalized carbonate-modified PEI polymers. (b) Antiviral activity (EC₅₀), cytotoxicity (CC₅₀), selectivity index (SI, CC₅₀/EC₅₀), and pH neutralization capacity of unmodified and mannose-functionalized PEI polymers. Prevention of DENV-2 infection in human primary peripheral blood mononuclear cells (PBMCs) (c) and macrophages (d) by PEI-man₆₅. ACE2, angiotensin-converting enzyme 2; PEI, poly(ethylene imine); PPAA, poly(propylacrylic acid); PVPA, poly(vinylphosphonic acid); PVBzA, poly(vinylbenzoic acid); SARS-CoV-2, severe acute respiratory syndrome–associated coronavirus 2.