Fig. 7.

(A) Schematic diagram of the targeted nanoparticles. Polyethylene glycol (PEG) molecules were endowed with adamantane (AD) to form inclusion complexes with surface CDs, which decorated the nanoparticle surface with PEG for steric stabilization and PEG-TF for targeting [99]. (B) 7C1 Synthesis scheme.7C1 nanoparticles were mixed with C14PEG2000 and siRNA in a high-throughput microfluidic chamber [97]. (C, a) Synthesis program for siRNA-PLGA conjugates via cleavable disulfide linkers. (b) Schematic illustration of the preparation of surface crosslinked siRNA-PLGA–conjugated microbubbles with cationic LPEI and their efficient intracellular uptake by polyelectrolyte charge interaction [95]. (D) Preparation of mannitol microparticles loaded with dendriplexes [107].