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. 2021 Mar 18;153(4):e202012685. doi: 10.1085/jgp.202012685

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© 2021 Iaparov et al.

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Figure 2. — Example geometric models of CRSs of different density types. (A) A compact square CRS with 20 RYRs arranged side by side on a 5 × 5 lattice; a = 150 nm. (B) A compact contact network CRS with 17 RYRs arranged side by side according to Walker et al., 2015. (C) A narrow CRS with 20 RYRs distributed according to pattern B (Table 1); a = 264 nm. (D) A wide CRS with 20 RYRs distributed according to pattern B (Table 1); a = 501 nm. The shadowed areas represent the planes of the CRSs. The empty squares with dots represent RYRs with a central ion channel, the point source of Ca²⁺ flux. The concentric circles of increasing diameter depict 2 µM [Ca²⁺] levels calculated for i_Ca of 0.04, 0.15, 0.25, and 0.4 pA, at which the steady-state open probability of a RYR would be 2% (see Fig. 1).