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. 2021 Mar 18;153(4):e202012685. doi: 10.1085/jgp.202012685

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© 2021 Iaparov et al.

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Figure 8. — Kinetics of averaged CREs in CRS models. The data were obtained from 10,000 simulated CREs generated for one typical CRS of each type and size. The narrow and wide CRS types were of pattern B. (A) The averaged time courses of quarks, blips, and sparks. Left: The range of CRS density types with N_RYR = 20 and i_Ca = 0.25 pA. Center: Narrow CRSs with N_RYR = 20 and the indicated range of i_Ca values. Right: Narrow CRSs with i_Ca of 0.25 pA and the indicated range of N_RYR values. The color coding is valid for individual columns only. (B) The amount of calcium ions n_Ca released during average quarks, blips, and sparks plotted against the respective RYR coupling strength φ with weight factor α (n_Ca of sparks not terminating within the simulation time are not shown). N_RyR, number of RYRs in the CRS.