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. 2021 Mar 18;153(4):e202012685. doi: 10.1085/jgp.202012685

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© 2021 Iaparov et al.

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Figure 9. — Relationships between characteristics of CREs and the coupling strength φ_i of the initiating RYR_i. The lines show the respective best global fit of all data points by functions ${\bar{A}}_{r e l_{i}},$ $F_{q_{i}} = 1 - F_{n q_{i}},$ $F_{b_{i}} = F_{n q_{i}} - F_{s_{i}},$ and $F_{s_{i}} .$ The best-fit parameters are given in Table 3. Indices i indicate pertinence to initiating RYR. Yellow, blue, red, and green symbols denote results for i_Ca values of 0.04, 0.15, 0.25, and 0.4 pA, respectively. The squares, circles, and triangles represent wide, narrow, and compact CRSs, respectively. Insets: The exemplar compact and narrow CRSs with 20 RYRs at i_Ca = 0.25 pA, both showing (average) response values for n = 10,000 simulations, 500 for each of the individual initiating RYRs, color-coded according to the look-up table bar (right) scaled for the range of the respective ordinates. $A_{r e l_{i}},$ average relative CRE amplitude; $F_{b_{i}}$ the fraction of blips; $F_{q_{i}},$ the fraction of quarks; $F_{s_{i}},$ the fraction of sparks.